Amyloidosis cutis dyschromica (ACD) is the rarest form of primary cutaneous amyloidosis (a category which also includes lichen, macular, and nodular amyloidosis, poikiloderma-like cutaneous amyloidosis, and primary cutaneous amyloidosis of the auricular concha). ACD was first described in 1970 and presents as widespread reticular hyperpigmentation with hypopigmented macules, typically not associated with pruritus. Onset is generally before puberty.

A few reported cases have occurred in patients with other systemic conditions, but systemic amyloidosis or other disease associations have not been established.

There does not appear to be any sex predilection for the disorder, but individuals of Asian descent have been reported most commonly in the literature. Multiple members of the same family may be affected; autosomal recessive and semidominant patterns of inheritance have been described. Mutations in the GPNMB gene have been implicated in ACD.