Acute chest syndrome
Sickle cell disease is the primary risk factor for ACS. Within the population with sickle cell disease, the following are predictors for increased risk of developing ACS: young age, low fetal hemoglobin, leukocytosis, genotypes HbSS (sickle cell anemia) and HbSβ0, asthma, tobacco exposure, recent surgery, or 3 or more severe veno-occlusive crises in the past year.
Management requires hospitalization for hydration, oxygenation, intravenous (IV) antibiotics, pain control, and blood transfusions and, in some cases, exchange transfusion.
Related topic: sickle cell acute pain crisis
J99 – Respiratory disorders in diseases classified elsewhere
372146004 – Acute chest syndrome
Differential Diagnosis & Pitfalls