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Allergic contact dermatitis - Oral Mucosal Lesion

See also in: Overview,Cellulitis DDx,External and Internal Eye,Anogenital,Hair and Scalp,Nail and Distal Digit
Contributors: Priyanka Vedak MD, Susan Burgin MD
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This summary discusses adult patients. Allergic contact dermatitis in children is addressed separately.

Allergic contact dermatitis (ACD) is a type IV hypersensitivity reaction. In the oral mucosa, it can occur due to topical agents (including those applied to the lips), ingested agents, or implanted materials.

ACD reactions to dental implants most frequently present as lichenoid reactions that appear reticulate, atrophic, erosive, or plaque-like in appearance. This is often seen on the mucosa in contact with the culprit material. However, it can also present as a more diffuse stomatitis or burning / painful sensation for the patient (ie, burning mouth syndrome). One series of 22 patients with burning mouth syndrome who underwent patch testing found that 27% of patients had possible relevant sensitization to dental metals. Another study examined patients with various oral diseases (gingivitis, oral stomatitis, cheilitis, etc) and found that allergen patch test results were frequently positive not only for metal allergens but also for flavorings and preservatives.

Reactions to polyether impression materials used by dentists have also been noted.

Allergic contact cheilitis (flaking of the lips) can occur due to allergens in toothpastes, whereas perioral ACD has been reported by patients treated by dentists wearing protective rubber gloves.


L23.9 – Allergic contact dermatitis, unspecified cause

40275004 – Contact dermatitis

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Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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Last Reviewed:10/02/2017
Last Updated:10/10/2017
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Patient Information for Allergic contact dermatitis - Oral Mucosal Lesion
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Allergic contact dermatitis is a delayed hypersensitivity reaction (the reaction to the allergen occurs 48–72 hours after exposure). The most common allergens causing allergic contact dermatitis often change with time, as certain chemicals come in or out of use in the manufacture of products that come in contact with the skin. Most recently, common causes of allergic contact dermatitis include nickel, chromates, rubber chemicals, and topical antibiotic ointments and creams. Frequent sensitizers in the general population also include fragrance, formaldehyde, lanolin (wool grease found in ointments and cosmetics), and a host of other common environmental chemicals.
  • Nickel is found in jewelry, belt buckles, metal closures on clothing, and some cell phones.
  • Chromates are used in the process of tanning leather for shoes and in cement, so they can affect construction workers who are in contact with cement.
  • Rubber chemicals are found in gloves, balloons, elastic in garments, mouse pads, and swim goggles.
  • Neomycin is common in triple antibiotic first aid ointments such as Neosporin (and generic versions of Neosporin) as well as other combination preparations with other antibacterials (eg, Polysporin). It may also be found in eye preparations and eardrops. Bacitracin is a common ingredient in antibiotic ointments and creams and can cause allergic contact dermatitis as well.
  • Common allergen-containing products include sunscreens (oxybenzone [benzophenone-3]), cosmetics, soaps, dyes, and jewelry.
  • Poison ivy is a frequent cause and is discussed separately.

Who’s At Risk

Allergic contact dermatitis can occur at any age in people of all ethnic backgrounds. Individuals with a skin condition (such as stasis dermatitis, otitis externa, or pruritus ani) requiring frequent application of topical agents can develop allergic contact dermatitis over time.

Signs & Symptoms

Allergic contact dermatitis may occur on any location of the body.
  • Scaly red to pink areas of elevated skin (papules and plaques) and blisters (vesicles) may be seen. Individual lesions have distinct borders and often have a geometric shape with straight edges and sharp angles.
  • Eyelid swelling is frequently seen when the allergen is unknowingly transferred from finger to lid. Affected areas are typically severely itchy.
  • When the dermatitis is long-standing, the areas of elevation become thick and secondary bacterial infection is possible.

Self-Care Guidelines

  • Avoid the offending agent.
  • It may be helpful to avoid common triggers, such as fragrance, lanolin, nickel, etc.
  • 1% over-the-counter hydrocortisone cream can be helpful in very mild cases. Topical (applied to the skin) antihistamines should be avoided.

When to Seek Medical Care

Seek medical evaluation for a persistent or recurrent rash of unknown origin. Your physician may perform patch testing to evaluate for potential contact allergies. Skin biopsy is sometimes used to confirm diagnosis.


Treatment is aimed at preventing contact with the allergen.
  • Symptomatic control of itching may include oral antihistamines.
  • Medium- and high-potency topical steroids may be prescribed for rashes occurring on the extremities or trunk.
  • Mild-potency topical steroids may be prescribed for thinner skin on the face and skin fold areas.
  • In severe cases involving large body areas, a course of an oral steroid (prednisone) may be prescribed.


Bolognia, Jean L., ed. Dermatology, pp.227, 252-256. New York: Mosby, 2003.

Freedberg, Irwin M., ed. Fitzpatrick's Dermatology in General Medicine. 6th ed, pp.266, 1164-1165. New York: McGraw-Hill, 2003.
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Allergic contact dermatitis - Oral Mucosal Lesion
See also in: Overview,Cellulitis DDx,External and Internal Eye,Anogenital,Hair and Scalp,Nail and Distal Digit
A medical illustration showing key findings of Allergic contact dermatitis : Erythema, Scaly plaque, Vesicle, Pruritus
Clinical image of Allergic contact dermatitis - imageId=1446. Click to open in gallery.  caption: 'A close-up of round and oval, pink plaques with scant scale.'
A close-up of round and oval, pink plaques with scant scale.
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