Aortoiliac occlusive disease, also known as Leriche syndrome, is a narrowing or blocking of iliac arteries caused by plaque buildup. It is a very common condition that typically occurs in older adult males, although any adult can be affected. Risk factors include smoking, hypercholesterolemia, hypertension, obesity, family history of heart disease, diabetes mellitus, Takayasu arteritis, or thromboangiitis obliterans. The most characteristic symptom is intermittent lower limb claudication defined by cramping in calf, thigh, hip, or buttock muscles following exercise. Other symptoms include erectile dysfunction, decreased femoral pulse, cold extremities, and/or signs of advancing disease such as ischemic ulcers on lower extremities, muscle weakness, and lower limb paresthesia.

Treatment includes lifestyle changes, endovascular therapy, and medication to decrease clotting risk.