Brown-McLean syndrome is the presence of peripheral edema and orange-brown pigmentation in the cornea of the eye. Brown-McLean syndrome is often asymptomatic, but may present as a foreign body sensation or pain in the eye. If edematous bullae rupture, the syndrome can rarely cause severe keratitis or corneal ulceration.

Brown-McLean is a complication of many intraocular procedures, including cataract extraction, phacoemulsification, lensectomy, and vitrectomy. It occurs years after a surgery. Its exact cause is unknown, though some patients may have a hereditary predisposition.

Brown-McLean is usually treated with lubrication, hyperosmotics, and observation.