Chloracne is a rare form of acne triggered by exposure to halogenated aromatic hydrocarbons such as dibenzofurans (PCDFs) and polychlorinated dibenzodioxins (PCDDs). Halogenated aromatic hydrocarbons are found in herbicides, insecticides, fungicides, and wood treatments.

Notably, chloracne is a symptom of dioxin poisoning, and while most cases are due to occupational exposure, the deliberate dioxin poisoning of Ukrainian President Victor Yushchenko demonstrates the plausibility of nonaccidental poisoning.

The sudden appearance of cysts, papules, and pustules typically follows chemical exposure by weeks to months. Systemic symptoms include fatigue, paresthesias, and hyperhidrosis. Liver abnormalities are common.