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Chronic mucocutaneous candidiasis - Nail and Distal Digit
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Chronic mucocutaneous candidiasis - Nail and Distal Digit

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Contributors: Shari Lipner MD, PhD, Bertrand Richert MD, Robert Baran MD, Susan Burgin MD
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Synopsis

Chronic mucocutaneous candidiasis : Erythema, Nail fold erythema and edema, Oral white plaque, Scaly plaques
Patients with chronic mucocutaneous candidiasis (CMC) have persistent or recurrent infections caused by Candida albicans of the mucous membranes, esophagus, skin, and nails. CMC is associated with acquired conditions, including human immunodeficiency virus (HIV), immunosuppression, protracted antibiotic treatment, and diabetes mellitus. CMC is also associated with inherited primary T-cell immunodeficiencies, such as severe combined immunodeficiencies, combined immunodeficiencies, autosomal-dominant hyper-IgE syndrome, and idiopathic CD4 lymphopenia. CMC disease (CMCD) is the presence of CMC in patients with no other defining clinical signs and no other genetic defects. Heterozygous STAT1 missense mutations are seen in patients with CMCD.

Nail involvement is common in patients with CMC. The affected nails often present with thickening, yellow-brown discoloration and subungual hyperkeratosis. Associated paronychia is common. There is often thickening of the soft tissues, resulting in a swollen distal phalanx that is more bulbous than clubbed.

Hyperkeratotic areas secondary to Candida invasion may develop in the proximal and lateral nail folds.

Codes

ICD10CM:
B37.2 – Candidiasis of skin and nail

SNOMEDCT:
234568006 – Chronic mucocutaneous candidiasis

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Last Reviewed:06/14/2017
Last Updated:02/14/2022
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Chronic mucocutaneous candidiasis - Nail and Distal Digit
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A medical illustration showing key findings of Chronic mucocutaneous candidiasis : Erythema, Nail fold erythema and edema, Oral white plaque, Scaly plaques
Clinical image of Chronic mucocutaneous candidiasis - imageId=800510. Click to open in gallery. caption: 'Fissuring, erosion, and erythema of the lips.'
Fissuring, erosion, and erythema of the lips.

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