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Collodion baby
Other Resources UpToDate PubMed

Collodion baby

Contributors: Craig N. Burkhart MD, Dean Morrell MD, Lowell A. Goldsmith MD, MPH
Other Resources UpToDate PubMed


A collodion baby should be considered a presentation rather than an actual diagnosis. Epidermolytic ichthyosis, congenital ichthyosiform erythroderma, lamellar ichthyosis, and several of other genodermatoses with ichthyosis as a component can present as a collodion baby. The newborn appears to be encased in a taut, shiny, thickened stratum corneum. The epidermis can become frayed very rapidly. Barrier function is diminished, and these neonates are at risk for dehydration. Breaks in the cutaneous barrier also place the newborn at risk for bacterial infections. In many cases, the membrane is shed and there is marked spontaneous improvement.


Q80.2 – Lamellar ichthyosis

205550003 – Collodion baby

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Differential Diagnosis & Pitfalls

  • Lamellar ichthyosis
  • Congenital nonbullous ichthyosiform erythroderma
  • Bullous congenital ichthyosiform erythroderma
  • Gaucher disease type 2
  • Trichothiodystrophy
  • Conradi disease
  • Sjögren-Larsson syndrome
  • Harlequin ichthyosis
  • Netherton syndrome

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Last Updated:02/03/2022
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Collodion baby
A medical illustration showing key findings of Collodion baby : Erythema, Present at birth, Taut, shiny skin, Widespread distribution
Clinical image of Collodion baby - imageId=579365. Click to open in gallery.  caption: 'Diffuse erythema with overlying shiny, wrinkled, membrane-like plaques on the scalp, neck, back, and arms.'
Diffuse erythema with overlying shiny, wrinkled, membrane-like plaques on the scalp, neck, back, and arms.
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