Crohn disease - Anogenital in
Symptoms from Crohn disease can vary considerably, both due to location but also to the severity of disease involvement. Patients may present with abdominal pain, bloody or nonbloody diarrhea, weight loss or malnutrition, fistulas, abscesses (often perianal), dysphagia, or oral ulcerations. Additionally, Crohn disease has many other extraintestinal manifestations that can at times be the presenting symptoms. These manifestations can involve joints, skin, eyes, vasculature, the lungs, or the kidneys. Chronic inflammation from Crohn disease can lead to fistula and stricture formation, which predispose to small and large bowel obstructions, infections secondary to fistula tracts, and malnutrition as a result of long-standing intestinal inflammation.
Although Crohn disease typically presents with gastrointestinal complaints, mucocutaneous findings including perianal lesions and genital lesions, when present, can precede the gastrointestinal complaints. Granulomatous infiltration of genital skin may compress lymphatics, leading to lymphedema of the vulva. Linear ulceration or aphthae may be present. True fistulas may occur.
Crohn disease presents most typically in the second to fourth decades of life, with a slight female predominance. While no clear genetic mutation is linked to the development of Crohn disease, there are many genetic mutations that are associated with Crohn disease. For unclear reasons, Crohn disease is more prevalent at higher latitudes and in certain patient populations, namely individuals of Ashkenazi Jewish descent and individuals of Northern European descent in the United States.
K50.918 – Crohn's disease, unspecified, with other complication
34000006 – Crohn's disease
Differential Diagnosis & Pitfalls
Drug Reaction Data