Cutaneous extramedullary hematopoiesis in Adult
(Of note, cutaneous extramedullary hematopoiesis is a normal occurrence during early embryogenesis, and it occurs until about the fifth month of gestation. Cutaneous extramedullary hematopoiesis in pre-term or full-term neonates is thought to be an accentuation of a normal physiologic process. These lesions resolve spontaneously 3-4 weeks after birth without intervention. Multiple reports suggest also that cutaneous extramedullary hematopoiesis in neonates may be precipitated by congenital infections, erythroblastosis fetalis, and twin transfusion syndrome.)
D75.9 – Disease of blood and blood-forming organs, unspecified
73241006 – Abnormal hematopoiesis
Differential Diagnosis & Pitfalls
- Marjolin ulcer – Usually seen in previously traumatized skin.
- Fungal infection – Fungal components are seen on skin biopsy.
- Stasis ulcer – Stasis changes are typically present.
- Langerhans cell histiocytosis – Skin biopsy reveals infiltrates of Langerhans cells in close approximation to the epidermis.
- Mycobacterial infection – Skin biopsy, cultures, and polymerase chain reaction (PCR) studies are positive for mycobacterium; look for a history of travel and exposure.
- Parasitic infestation – Parasites are seen on skin biopsy; look for a history of travel and exposure.
- Chemical burn – Look for a history of chemical injury.
- Thermal burn – Look for a history of thermal injury.
- Radiation damage – Look for a history of radiation injury.
- Trauma – Look for a history of trauma.