Diffuse large B-cell lymphoma
DLBCL is more frequent in older individuals (median age is 64 years) and shows a slightly male predominance. Patients with a history of solid organ transplant, immunodeficiency, B-cell-activating autoimmune disorders (systemic lupus erythematosus, Sjögren syndrome, celiac disease), or occupational exposure to agricultural pesticides or ionizing radiation may be at increased risk.
There are many subtypes of DLBCL characterized by distinct morphologies, locations, and/or molecular signatures. A very rare subtype of large B-cell lymphoma is intravascular B-cell lymphoma, which is often difficult to diagnosis due to vague nonspecific symptoms and is usually aggressive. Another uncommon but aggressive subtype is DLBCL, leg type. It usually presents as red or violaceous plaques on the lower leg but can occur at any body location. The lesions may quickly develop into tumors that ulcerate.
Patients may present with nodal or extranodal disease (the most common extranodal site is the gastrointestinal tract) or a mass that is rapidly enlarging. B symptoms (fever, weight loss, night sweats) are present, but asymptomatic presentations can also occur.
C83.30 – Diffuse large B-cell lymphoma, unspecified site
109969005 – Diffuse non-Hodgkin's lymphoma, large cell
- Other lymphomas including Burkitt lymphoma and anaplastic T-cell lymphoma
- Infectious mononucleosis (Epstein-Barr virus [EBV] infection)
- Other infectious lymphadenitis (eg, cat scratch fever)
- Other systemic or indolent infections that present with B symptoms (endocarditis, osteomyelitis, tuberculosis)
- Other cancers (carcinoma, melanoma, sarcoma)