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Diffuse scleritis - External and Internal Eye
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Diffuse scleritis - External and Internal Eye

Contributors: Brandon D. Ayres MD, Christopher Rapuano MD, Harvey A. Brown MD, Sunir J. Garg MD, Lauren Patty Daskivich MD, MSHS
Other Resources UpToDate PubMed


Diffuse anterior scleritis is one of the most commonly encountered forms of scleritis. Scleritis is an inflammatory condition affecting the sclera that is often associated with underlying systemic collagen vascular disease, vasculitis, or other auto-immune disease. Scleritis causes severe injection of the sclera and ocular pain. It is most commonly seen in middle-aged women. As scleritis often stems from an underlying systemic condition, it tends to affect both eyes and can be quite asymmetric. The scleral inflammation can affect adjacent tissues and, many times, the peripheral cornea can become involved and cause visual loss.


H15.099 – Other scleritis, unspecified eye

91612009 – Diffuse scleritis

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Diffuse episcleritis
  • Nodular episcleritis
  • Nodular scleritis
  • Viral conjunctivitis
  • Bacterial conjunctivitis
  • Allergic conjunctivitis
  • Necrotizing scleritis
  • Uveitis
  • Vasculitis
  • Contact lens solution toxicity
  • Toxic conjunctivitis

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Management Pearls

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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Last Updated:08/17/2021
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Diffuse scleritis - External and Internal Eye
A medical illustration showing key findings of Diffuse scleritis : Eye pain, Blurred vision, Photophobia, Bilateral distribution, Conjunctival injection, Excessive tearing
Clinical image of Diffuse scleritis - imageId=3103267. Click to open in gallery.
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