An ankle dislocation, also known as a tibiotalar dislocation, occurs when enough force is applied to the ankle that that distal tibia and talar dome are not congruent. This can occur after a high-energy mechanism including a motor vehicle crash, a sports injury, or a fall. A lower-energy twisting injury can also lead to dislocation.

Ankle dislocation is almost always associated with ankle fracture, although ankle dislocations without fracture have been reported. Dislocations are always described with regard to the distal bone, such as the position of the talus with respect to the tibia. This injury is characterized by pain, swelling, and deformity of the ankle.

Ankle dislocation can occur in people of any age, but these injuries are most common in young men. Chronic ankle instability / laxity is a risk factor.