SynopsisCodesDrug Reaction Data
Drug-induced weight gain
Other Resources UpToDate PubMed

Drug-induced weight gain

Other Resources UpToDate PubMed


Unintended increase in body weight following use of certain medications. The precise mechanism is complex, and involves metabolic, hormonal, behavioral, and appetite changes. Unintended progressive weight gain can contribute to dyslipidemia, insulin resistance, obesity, and the increased risk of cardiovascular disease and diabetes.

Medications associated with weight gain include antipsychotics (especially second generation antipsychotics such as clozapine and olanzapine), antidepressants (lithium, amitriptyline, clomipramine, imipramine, doxepin, trimipramine, and some SSRIs), antidiabetics (pioglitazone, rosiglitazone), anticonvulsants (carbamazepine, valproic acid, gabapentin, and pregabalin with thiazolidinedione), and hormonal therapy.

Management of medication-induced weight gain includes patient education, weight-maintenance diet, physical activity, exploration of alternative medications, and dosage adjustment. Metformin has been found to help reduce weight gain caused by certain medications.


T50.995A – Adverse effect of other drugs, medicaments and biological substances, initial encounter

8943002 – Weight gain

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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Last Updated:12/07/2016
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Drug-induced weight gain
A medical illustration showing key findings of Drug-induced weight gain : Weight gain
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