Erosive adenomatosis of the nipple
Peak incidence is in the fifth decade for women. On rare occasions, men and children may develop the condition (usually girls but also reported in boys). The development of the condition is insidious, making diagnosis often incidental or late.
EAN may be asymptomatic, although common symptoms include breast discharge (serous, serosanguinous, or bloody), crusting, pain, and itching. In early stages, pain and pruritus are common, while in later stages, deformities of the nipple and nipple nodularity are more common. EAN is typically unilateral but may occur bilaterally.
Risk factors may include female sex, use of oral contraceptives, and obesity.
N64.59 – Other signs and symptoms in breast
237467005 – Erosive adenomatosis of nipple
Differential Diagnosis & Pitfalls
- Paget disease
- Ductal carcinoma in situ (DCIS) – Can be differentiated histopathologically.
- Intraductal papilloma – Has intraductal growth with prominent myoepithelial cells.
- Syringomatous adenoma of the nipple
- Subareolar sclerosing duct hyperplasia
- Nummular dermatitis
- Contact dermatitis
- Atopic dermatitis
- Hyperkeratosis of nipple