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Erythema toxicum neonatorum
Other Resources UpToDate PubMed

Erythema toxicum neonatorum

Contributors: Craig N. Burkhart MD, Dean Morrell MD, Lowell A. Goldsmith MD, MPH
Other Resources UpToDate PubMed


Erythema toxicum neonatorum is a common, benign skin eruption of uncertain cause that affects newborns. It is seen in term infants and is rare in the premature. The rash develops in most infants between the second and fourth day of life and resolves within hours to days.


P83.88 – Other specified conditions of integument specific to newborn

240302002 – Erythema toxicum neonatorum

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Differential Diagnosis & Pitfalls

Vesiculopustular rashes in the neonate may be divided into infectious, transient, or persistent dermatoses.

Infectious vesiculopustular dermatoses:
  • Congenital candidiasis
  • Cytomegalovirus infection of newborn
  • Primary cutaneous aspergillosis of premature infants
  • Neonatal herpes simplex virus
  • Neonatal varicella
  • Scabies
  • Superficial staphylococcal infection
  • Neonatal listeriosis
  • Haemophilus influenza
  • Group A streptococcal infection
  • Pseudomonas
Transient noninfectious vesiculopustular dermatoses:
  • Transient neonatal pustular melanosis
  • Miliaria crystallina and Miliaria rubra
  • Neonatal acne
  • Acropustulosis of infancy
  • Pustular eruption in Down syndrome
Persistent noninfectious vesiculopustular dermatoses:
  • Incontinentia pigmenti
  • Eosinophilic pustular folliculitis in infancy
  • Langerhans cell histiocytosis
  • Hyperimmunoglobulinemia E syndrome
  • Pustular psoriasis

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Last Updated:03/11/2019
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Patient Information for Erythema toxicum neonatorum
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Erythema toxicum neonatorum
A medical illustration showing key findings of Erythema toxicum neonatorum : Developed during first days to week of life, Primarily truncal distribution, Scattered few, Widespread distribution
Clinical image of Erythema toxicum neonatorum - imageId=1149248. Click to open in gallery.  caption: 'Multiple erythematous papules and pustules and background erythema on the face, neck, and torso.'
Multiple erythematous papules and pustules and background erythema on the face, neck, and torso.
Copyright © 2024 VisualDx®. All rights reserved.