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Erythroplasia of Queyrat - Anogenital in
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Erythroplasia of Queyrat - Anogenital in

See also in: Overview
Contributors: Gaurav Singh MD, MPH, Susan Burgin MD
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Erythroplasia of Queyrat (EPQ) is a squamous cell carcinoma in situ (SCCIS) of the glans penis. The disorder is rare and comprises less than 1% of malignancies that affect males. It should be considered a type of Bowen disease, which is SCCIS at any location. The lesion is a precursor for invasive squamous cell carcinoma (SCC) and is unlikely to remit spontaneously.

EPQ classically presents as a well-demarcated, velvety, erythematous plaque, but its appearance may be variable.

The entity is considered a high-grade squamous intraepithelial lesion / neoplasia (HSIL) histologically. It is most commonly due to human papillomavirus (HPV) type 16. HPV types 18, 26, 31, 33, and 53 have also been implicated. It is more common in elderly, uncircumcised males. EPQ and penile cancer in general has a much higher incidence in non-Western countries likely due to cultural circumcision habits, as circumcision reduces risk.

Risk factors believed to contribute to the development of EPQ include lack of circumcision, Zoon balanitis, HPV infection, immunosuppression (such as human immunodeficiency virus [HIV] infection), ultraviolet (UV) light exposure, phimosis, multiple sexual partners, smoking, other underlying dermatoses (lichen sclerosis, erosive / hypertrophic lichen planus), and any form of chronic irritation, inflammation, or infection. Examples of chronic insults include trauma, herpes simplex virus infection, heat, friction, trauma, urine, and smegma.

If left untreated, EPQ will eventually develop into invasive SCC in one-third of cases.


D07.4 – Carcinoma in situ of penis

398768004 – Erythroplasia of Queyrat

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Differential Diagnosis & Pitfalls

Inflammatory conditions:
  • Erosive balanitis
  • Balanoposthitis
  • Balanitis circumscripta plasmacellularis (Zoon plasma cell balanitis)
  • Balanitis xerotica obliterans
  • Psoriasis
  • Lichen planus
  • Fixed drug eruption
  • Allergic contact dermatitis
  • Irritant contact dermatitis
  • Pemphigus vulgaris
  • Pemphigus foliaceus
  • Mucous membrane pemphigoid
  • Keratoderma blennorrhagicum
Infectious conditions:
  • Genital herpes simplex virus (HSV)
  • Male genital candidiasis
Neoplastic conditions:
  • Basal cell carcinoma (see, eg, Superficial basal cell carcinoma)
  • Melanoma
  • Squamous cell carcinoma in situ
  • Cutaneous squamous cell carcinoma
  • Bowenoid papulosis
  • Extramammary Paget disease
  • Kaposi sarcoma (AIDS-associated Kaposi sarcoma and Non-AIDS Kaposi sarcoma)

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Last Reviewed:09/19/2018
Last Updated:10/15/2018
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Erythroplasia of Queyrat - Anogenital in
See also in: Overview
A medical illustration showing key findings of Erythroplasia of Queyrat : Foreskin, Glans of penis, Skin erosion, Dysuria, Pruritus
Clinical image of Erythroplasia of Queyrat - imageId=2079331. Click to open in gallery.  caption: 'A well-demarcated, scaly, and crusted, erythematous plaque on the distal penis.'
A well-demarcated, scaly, and crusted, erythematous plaque on the distal penis.
Copyright © 2024 VisualDx®. All rights reserved.