Fixed drug eruption - Anogenital in
FDE is most commonly solitary, but some individuals may develop multiple patches. There may be an increasing number of patches seen with each exposure. Healing with postinflammatory hyperpigmentation is common.
Numerous drugs have been implicated in causing FDE. The most commonly associated drug classes for FDE in the anogenital region are also the most frequently seen culprit medications for FDE in general. These medication classes include antibiotics, in particular sulfonamides, trimethoprim, and tetracyclines, and NSAIDs, including naproxen, ibuprofen, and celecoxib. Other drugs implicated in FDE include amoxicillin, erythromycin, metronidazole, fluconazole, paracetamol (acetaminophen), cetirizine, hydroxyzine, methylphenidate, oral contraceptives, quinine, and phenolphthalein. Biologic agents including ustekinumab, adalimumab, and abatacept have been reported to cause fixed drug eruptions. A nonpigmenting version of this condition is seen with pseudoephedrine.
L27.1 – Localized skin eruption due to drugs and medicaments taken internally
73692007 – Fixed drug eruption
Differential Diagnosis & Pitfalls
Drug Reaction Data