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Fox-Fordyce disease
See also in: Anogenital
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Fox-Fordyce disease

See also in: Anogenital
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Contributors: Vivian Wong MD, PhD, Mat Davey MD, Mary Gail Mercurio MD, Susan Burgin MD
Other Resources UpToDate PubMed

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Synopsis

Fox-Fordyce disease : Areola, Axilla, Female genital, Follicular configuration, Intertriginous distribution, Pruritus, Tiny papules
Fox-Fordyce disease is a rare inflammatory condition of apocrine gland-bearing regions caused by obliteration of the follicular infundibulum with keratin. The etiology is unknown, although an endocrine role has been postulated. The disease manifests as intensely pruritic, skin-colored or keratotic papules in the axillary, anogenital, umbilical, and periareolar areas. Heat, humidity, stress, and other external stimuli such as laser hair removal may worsen symptoms and lead to appearance of new papules.

It is most common in females between puberty and age 35. Less commonly, it can affect male patients, prepubescent girls, and postmenopausal women. It may flare perimenstrually and improve during pregnancy and after menopause.

Codes

ICD10CM:
L75.2 – Apocrine miliaria

SNOMEDCT:
65038009 – Fox-Fordyce disease

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed:01/31/2021
Last Updated:02/01/2021
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Fox-Fordyce disease
See also in: Anogenital
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A medical illustration showing key findings of Fox-Fordyce disease : Areola, Axilla, Female genital, Follicular configuration, Intertriginous distribution, Pruritus, Tiny papules
Clinical image of Fox-Fordyce disease - imageId=96390. Click to open in gallery. caption: 'Numerous hyperpigmented, monomophic, follicular-based papules in the axilla.'
Numerous hyperpigmented, monomophic, follicular-based papules in the axilla.

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