Gilbert disease is an autosomal recessive liver disorder characterized by unconjugated hyperbilirubinemia, resulting in harmless intermittent jaundice. Enzyme inactivity of UDP-glucuronosyltransferase 1A1 (UGT1A1) gene is responsible for this liver disorder. Also known as familial nonhemolytic jaundice or constitutional hepatic dysfunction, Gilbert syndrome is characterized by recurring episodes of fatigue, malaise, hyperbilirubinemia (unconjugated), and jaundice and is often discovered inadvertently during laboratory tests. Although present at birth, symptoms may not manifest until late puberty.
Gilbert disease may predispose patients to increased adverse effects of certain medications and has been associated with an increased risk for gallstones.
No treatment is needed, and long-term outcomes are equivalent to those of the general population.