Granular cell myoblastoma is a slow-growing submucosal tumor derived from the nerve sheath. It is located on the vulva in approximately 10% of cases, although it is more commonly seen in the nasopharyngeal area, particularly on the tongue. It can be multifocal.
Granular cell myoblastoma is seen most commonly in adults, but it presents in children as well. The median age at diagnosis is between 30 and 50 years. It is more common among Black women.
The majority of cases of granular cell myoblastoma are benign, but 2% are found to be malignant. They can recur; thus, surveillance is warranted.
Related topic: granular cell tumor
Granular cell myoblastoma of vulva - Anogenital in
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Synopsis
Codes
ICD10CM:
D17.30 – Benign lipomatous neoplasm of skin and subcutaneous tissue of unspecified sites
SNOMEDCT:
404035005 – Granular cell myoblastoma
D17.30 – Benign lipomatous neoplasm of skin and subcutaneous tissue of unspecified sites
SNOMEDCT:
404035005 – Granular cell myoblastoma
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Differential Diagnosis & Pitfalls
- Associated pseudoepitheliomatous hyperplasia on a mucocutaneous surface can be misinterpreted as cancer. Careful slide review is recommended.
- Sebaceous cyst – Smooth, encapsulated subdermal mass filled with purulent fluid. Ultrasound will reveal a fluid-filled mass rather than a solid soft-tissue mass consistent with granular cell myoblastoma.
- Lipoma – Soft subcutaneous mass composed of adipose tissue. Excision and pathology review will differentiate from granular cell myoblastoma.
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Last Reviewed:01/03/2021
Last Updated:10/27/2021
Last Updated:10/27/2021
Granular cell myoblastoma of vulva - Anogenital in