Harlequin color change of newborn
Most cases are idiopathic in healthy neonates. HCC has also been noted in the setting of prematurity, low birth weight, hypoxia, infusion of prostaglandin E1 (PGE1), and neonatal meningitis.
The transient color change lasts anywhere from 30 seconds to 20 minutes and recurs up to 12 times over a period of 24 hours. Of note, typical HCC occurs without changes in vital signs, pain, or other signs or symptoms. Hemiscrotal- and hemifacial-limited variants as well as a patchy erythema variant have been reported.
P29.89 – Other specified conditions originating in the perinatal period
276697006 – Harlequin change
- Cutis marmorata – Transient reddish-purple, reticulated mottling of the skin that involves the trunk and extremities.
- Cutis marmorata telangiectatica congenita – Reticular erythematous or violaceous patches on one or more extremity, sometimes involving the trunk.
- Port-wine stain – A fixed partially or completely blanchable pink or red patch, with unilateral or segmental distribution that respects the midline.
- Nascent hemangioma of infancy – Bright red papule, nodule, or plaque raised above clinically normal skin. Typically not evident at birth, but becomes apparent within the first days to months of life.
- CHILD syndrome – X-linked dominant disorder characterized by congenital hemidysplasia, ichthyosiform erythroderma, and limb defects. The skin involvement is unilateral, with a sharp midline demarcation, and consists of circumscribed linear plaques covered by waxy scales.
- Vaso-occlusive complications from central catheters
- Viral infection
- Drug reaction