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SynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyReferences
Juvenile myoclonic epilepsy
Other Resources UpToDate PubMed

Juvenile myoclonic epilepsy

Contributors: Jamie Adams MD, Richard L. Barbano MD, PhD
Other Resources UpToDate PubMed

Synopsis

Juvenile myoclonic epilepsy (JME) is an idiopathic generalized epilepsy syndrome that typically starts around puberty. Seizures are characterized by bilateral irregular myoclonic jerks without loss of consciousness that usually occur shortly after awakening and may be precipitated by sleep deprivation. Patients may also have generalized tonic-clonic seizures and, less commonly, absence seizures. Most patients have lifelong seizures, although with appropriate treatment, seizure control occurs in up to 80% of cases. Cognitive dysfunction, behavioral disturbances, and psychiatric disorders may also be present.

Heterozygous variants in intestinal cell kinase (ICK) can cause a form of JME.

Codes

ICD10CM:
G40.B09 – Juvenile myoclonic epilepsy, not intractable, without status epilepticus

SNOMEDCT:
6204001 – Juvenile myoclonic epilepsy

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Other generalized epilepsy syndromes (eg, Childhood absence epilepsy)
  • Progressive myoclonic epilepsy (eg, Lafora disease)
  • Movement disorders (eg, myoclonus, tics, Hemifacial spasm)
  • Drug-induced myoclonus
  • Transient ischemic attacks / Cerebral stroke
  • Migraine headache
  • Syncope summary
  • Psychogenic nonepileptic events (Somatic symptom and related disorders)

Best Tests

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Management Pearls

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Therapy

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References

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Last Reviewed:02/15/2017
Last Updated:10/10/2022
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Juvenile myoclonic epilepsy
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A medical illustration showing key findings of Juvenile myoclonic epilepsy : Bilateral myoclonic jerks
Copyright © 2024 VisualDx®. All rights reserved.