Contents

SynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyReferences

View all Images (12)

Leiner disease
Other Resources UpToDate PubMed

Leiner disease

Contributors: Craig N. Burkhart MD, Dean Morrell MD, Lowell A. Goldsmith MD, MPH
Other Resources UpToDate PubMed

Synopsis

Leiner disease is a clinical phenotype marked by the triad of noncongenital or acquired erythroderma, diarrhea, and failure to thrive. Leiner disease may not represent a distinct clinical entity because infants with the clinical phenotype have eventually been diagnosed with various other conditions, including congenital immunodeficiencies, Netherton syndrome, Omenn syndrome, and eosinophilic gastroenteritis. Affected infants develop an acquired generalized desquamative dermatitis within the first few weeks of life. They also suffer from diarrhea, weight loss, and failure to thrive.

Codes

ICD10CM:
L21.1 – Seborrheic infantile dermatitis

SNOMEDCT:
7297005 – Leiner's disease

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

References

Subscription Required

Last Updated:10/06/2022
Copyright © 2022 VisualDx®. All rights reserved.
Leiner disease
A medical illustration showing key findings of Leiner disease : Diarrhea, Desquamation, Erythroderma, Failure to thrive
Clinical image of Leiner disease - imageId=1167751. Click to open in gallery.  caption: 'Diffuse erythema and overlying flaky scale on the face and ear.'
Diffuse erythema and overlying flaky scale on the face and ear.
Copyright © 2022 VisualDx®. All rights reserved.