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Libman-Sacks endocarditis
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Libman-Sacks endocarditis

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Contributors: Benjamin L. Mazer MD, MBA, Ryan Hoefen MD, PhD, Jeffrey P. Callen MD, FACP, MAAD, MACR
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Synopsis

Libman-Sacks endocarditis : Exertional dyspnea, Heart murmur, Dyspnea, Asthenia
Libman-Sacks endocarditis is a noninfective cardiac valve disease that was initially described in patients with systemic lupus erythematosus (SLE). After the recognition that antiphospholipid antibodies were associated with this phenomenon frequently, it has become possible that this form of endocarditis might occur in patients with antiphospholipid antibody syndrome in the absence of a diagnosis of SLE. Vegetations on cardiac valves in Libman-Sacks endocarditis are composed primarily of inflammatory cells and fibrin clots. Endocarditis is presumed to be caused by autoimmunity against a cardiac valve with concurrent hypercoagulability. Patients are often asymptomatic but may be discovered after a cardioembolism causes ischemic injury, such as stroke or peripheral embolic disease. Libman-Sacks endocarditis is most frequently on the mitral and/or aortic valves. It may cause valve dysfunction.

Treatment includes anticoagulation, immunosuppression for active SLE, and valve replacement in cases complicated by severe dysfunction.

Codes

ICD10CM:
M32.11 – Endocarditis in systemic lupus erythematosus

SNOMEDCT:
54072008 – Nonbacterial verrucal endocardiosis

Differential Diagnosis & Pitfalls

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Last Updated:05/02/2022
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Libman-Sacks endocarditis
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A medical illustration showing key findings of Libman-Sacks endocarditis : Exertional dyspnea, Heart murmur, Dyspnea, Asthenia
Copyright © 2023 VisualDx®. All rights reserved.