Lipoatrophic panniculitis of children
Although this condition can affect adults, it is more common in children, predominantly affecting ages 3-13 years, and girls are affected more frequently than boys. Fewer than 5 of the reported cases to date have also presented with hepatomegaly or splenomegaly.
While the cause of lipoatrophic panniculitis is unknown, it may be associated with other autoimmune or autoinflammatory conditions (eg, insulin-dependent diabetes mellitus, Hashimoto thyroiditis, and juvenile rheumatoid arthritis). Neither physical trauma nor specific viral etiologies have been linked, although prior upper respiratory infections have been reported in some patients prior to onset. A genetic link has been postulated but not confirmed. One report suggests that a mutation in chromosome 10p (where alleles for the interleukin-2 [IL-2] receptor gene reside) is implicated.
M79.3 – Panniculitis, unspecified
238881001 – Lipoatrophic panniculitis
- Erythema nodosum – Often seen in young adult women; appears as reddish nodules on the anterior lower legs.
- Granulomatous panniculitis
- Subcutaneous sarcoidosis
- Cutaneous polyarteritis nodosa
- Post-steroid panniculitis
- Lupus panniculitis
- Mixed connective tissue disease
- Traumatic panniculitis – Usually localized in one area and described in patient history.
- Cold panniculitis – Look for history of prolonged cold exposure. Can be seen in either children or adults.
- CANDLE syndrome
- Joint contractures-muscular atrophy-microcytic anemia-panniculitis-associated lipodystrophy (JMP) syndrome
- Nakajo-Nishimura syndrome
- Eosinophilic fasciitis