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Löfgren syndrome
Other Resources UpToDate PubMed

Löfgren syndrome

Contributors: Benjamin L. Mazer MD, MBA
Other Resources UpToDate PubMed


Löfgren syndrome is a constellation of symptoms that is nearly always suggestive of acute sarcoidosis. The primary symptoms are erythema nodosum and hilar lymphadenopathy. Arthritis, uveitis, and fever also frequently occur. Primary tuberculosis can rarely present with hilar lymphadenopathy and erythema nodosum. The simultaneous presence of all the typical features of Löfgren syndrome, however, is highly specific for sarcoidosis.

Löfgren syndrome predominantly occurs in female patients of Northern European descent. Unlike other manifestations of sarcoidosis, Löfgren syndrome usually resolves within 2 years and rarely relapses. NSAIDs are the typical treatment, with immunosuppression sometimes required.


D86.86 – Sarcoid arthropathy

238676008 – Lofgrens syndrome

Differential Diagnosis & Pitfalls

Differential diagnosis depends on presenting symptoms.

See erythema nodosum for a differential of skin findings, and also consider:
Hilar lymphadenopathy:

Best Tests

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Last Updated:05/26/2016
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Löfgren syndrome
A medical illustration showing key findings of Löfgren syndrome : Fever, Hilar lymphadenopathy, Malaise, Migrating polyarthralgia, Arthralgia
Copyright © 2023 VisualDx®. All rights reserved.