Lyme disease is caused by an infection with Borrelia burgdorferi. The typical host for this organism is the deer tick, but humans can become infected if bitten. Very often, patients will not recall a tick bite. The initial signs of Lyme disease include fever and chills, an annular expanding bulls-eye rash (erythema migrans), joint swelling, and muscle pain. Borrelia burgdorferi is very hard to culture, and diagnosis usually relies on serologic positivity. It is very rare for early Lyme disease to affect the eye; however, patients diagnosed and treated in the late stage can have manifestations in the eye. These patients will typically complain of eye redness, pain, light sensitivity, or reduced vision due to ocular inflammation.