The multiple lentigines syndrome, also known as Noonan syndrome with multiple lentigines, LEOPARD syndrome, Gorlin syndrome II, cardio-cutaneous syndrome, lentiginosis profuse syndrome, and progressive cardiomyopathic lentiginosis, is one of the familial lentiginosis syndromes, a group of genetic disorders that are characterized by the presence of multiple lentigines as well as an increased incidence of cardiovascular, endocrine, and gastrointestinal neoplasias.

LEOPARD is an acronym for multiple lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonary stenosis, abnormal genitalia, retardation of growth, and sensorineural deafness. Some patients with this condition may also exhibit mild intellectual disability or speech difficulties. This syndrome occurs as a result of a mutation in the Noonan syndrome gene (a condition to which it is allelic), PTPN11. As a result, patients with LEOPARD syndrome commonly share clinical features with people who have Noonan syndrome. Although most cases result from sporadic mutations, the syndrome follows an autosomal dominant pattern of inheritance.

Lentigines present as small, asymptomatic, well-circumscribed, symmetric, homogenous, hyperpigmented macules. In LEOPARD, lentigines are usually small, < 5 mm in size, and tend to predominate on the trunk, but other areas may be involved, such as the palms, soles, buccal mucosa, genitalia, and scalp. Individual larger pigmented macules ranging in size from 1 to 1.5 mm may also be present. Patients tend to have a "speckled" appearance. Lentigines generally occur early in life (may be present at birth) and are not associated with sun exposure. Lentigines found on mucous membranes can be deeply pigmented, with increased size and irregular borders.