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Neuroblastoma in Child
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Neuroblastoma in Child

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Contributors: Andrea Wasilewski MD, Jamie Adams MD, Richard L. Barbano MD, PhD
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Synopsis

Neuroblastoma : Abdominal pain, Fever, Joint pain, Abdominal mass, Bone pain, Hematuria, Regional lymphadenopathy, Thrombocytosis, Anemia, Proptosis
Neuroblastoma is a neuroendocrine tumor that arises from neural crest cells. It is the most common solid tumor of infancy and childhood; typical age of onset is less than 3 years old. The adrenal glands are the most frequent site of origin, but this tumor can be found anywhere along the sympathetic nervous system chain including the neck, chest, abdomen, or pelvis. Presenting symptoms depend on the site of origin and areas of metastasis if present but may be nonspecific including fatigue, fevers, anorexia, abdominal pain, or joint or bone pains. Less common symptoms include weakness, ataxia, chronic diarrhea, hypertension, or shortness of breath. The presence of Horner syndrome or opsoclonus-myoclonus syndrome in children should prompt evaluation for this type of tumor.

Treatment and prognosis depend on whether the tumor is low, intermediate, or high risk. Metastases are associated with a high mortality rate.

Codes

ICD10CM:
C74.90 – Malignant neoplasm of unspecified part of unspecified adrenal gland

SNOMEDCT:
432328008 – Neuroblastoma

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Differential Diagnosis & Pitfalls

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Therapy

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References

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Last Reviewed:02/10/2019
Last Updated:02/28/2019
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Neuroblastoma in Child
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A medical illustration showing key findings of Neuroblastoma : Abdominal pain, Fever, Joint pain, Abdominal mass, Bone pain, Hematuria, Regional lymphadenopathy, Thrombocytosis, Anemia, Proptosis
Imaging Studies image of Neuroblastoma - imageId=8343616. Click to open in gallery. caption: '<span>T2 sagittal MRI of thorax showing large neuroblastoma along the mid thoracic spine.</span>'
T2 sagittal MRI of thorax showing large neuroblastoma along the mid thoracic spine.
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