Nevus depigmentosus in Adult
Most patients will have just one macule or patch, although there are reports of patients having as many as 10. In cases where there are numerous lesions, other diagnoses should be considered. There are no particular sites of predilection.
Nevus depigmentosus is distinguished from vitiligo by a very different clinical course. Vitiligo is an acquired (and not congenital) pigmentary disorder with an unpredictable natural course, with individual lesions presenting abruptly, which may progress or regress. Lesions in vitiligo are depigmented, whereas lesions in nevus depigmentosus are hypopigmented. Furthermore, the distribution of vitiligo is symmetric, with predilection for the face and areas subject to repeated friction, such as hands, feet, and genitals.
There are no associated systemic abnormalities with nevus depigmentosus, and lesions do not have malignant potential.
L81.8 – Other specified disorders of pigmentation
403541001 – Nevus depigmentosus
Differential Diagnosis & Pitfalls