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Oral fibroma - Oral Mucosal Lesion
Other Resources UpToDate PubMed

Oral fibroma - Oral Mucosal Lesion

Contributors: Carl Allen DDS, MSD, Sook-Bin Woo MS, DMD, MMSc
Other Resources UpToDate PubMed


The oral fibroma is a tumor-like mass of fibrous scar tissue caused by chronic trauma, typically a bite injury. There is no sex predilection and any age group may be affected.

The patient notices a painless (unless recently bitten) nodule that is located at sites easily bitten, such as the lower labial mucosa, lateral tongue, and buccal mucosa.


D10.30 – Benign neoplasm of unspecified part of mouth

128046007 – Disease of oral mucosa

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Differential Diagnosis & Pitfalls

  • Lipoma – These are generally yellow, but some contain more fibrous tissue and appear pink.
  • Oral papilloma
  • Granular cell tumor
  • Benign salivary gland tumor – These tend to be more firm and somewhat more deep-seated.
  • Malignant salivary gland tumor
  • Lobular capillary hemangioma (pyogenic granuloma) – Tends to be reddish-purple in color.
  • Soft tissue tumors (eg, neural tumors)
  • Medication-associated fibrous nodules – Occur in patients on cyclosporine after allogenic hematopoietic stem cell transplantation.
  • Oral mucocele – Dome-shaped, bluish, and fluid-filled, but they may become sclerosed, organized, and fibrotic over time.
  • Giant cell fibroma – A histologic variant, it has a papillary rather than smooth surface and is located mainly on the gingiva, tongue, and palate.
  • Cowden disease – Presents with not solitary but multiple fibrous nodules and papules in the oral mucosa with typical concomitant skin tumors.

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Last Updated:10/30/2017
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Oral fibroma - Oral Mucosal Lesion
A medical illustration showing key findings of Oral fibroma : Buccal mucosa, Mucosal lip, Oral papule, Tongue, Oral nodule
Clinical image of Oral fibroma - imageId=2098244. Click to open in gallery.  caption: 'A whitish nodule on the buccal mucosa.'
A whitish nodule on the buccal mucosa.
Copyright © 2024 VisualDx®. All rights reserved.