Papuloerythroderma of Ofuji
PEO mostly affects men of Asian or Northern European descent, with onset at age 55 years or older. These patients are typically healthy, and PEO is usually idiopathic. However, etiological associations have been noted in a minority of cases, including an underlying atopic diathesis, hematologic malignancies, gastric and other solid organ malignancies, and, less frequently, drugs (such as aspirin and furosemide) and infections (such as hepatitis C virus [HCV] and human immunodeficiency virus [HIV]). Additionally, cases of cutaneous T-cell lymphoma (CTCL) with a PEO-like clinical appearance have been reported.
PEO is generally an indolent condition and requires long-term treatment. Those with secondary PEO may experience faster and complete resolution upon treatment of underlying conditions or cessation of offending drugs.
L53.9 – Erythematous condition, unspecified
402299006 – Papuloerythroderma of Ofuji
Differential Diagnosis & Pitfalls
Drug Reaction Data