Piezogenic papules are common and benign lesions that occur due to herniations of subcutaneous fat through the dermis when pressure is applied. Most commonly encountered on the heels when standing or walking, they can also be seen when the hand flexes at the wrist. As they are related to pressure, they have been reported to occur more frequently in obese individuals and in athletes including skaters and dancers. Piezogenic papules have also been reported more commonly in patients with Ehlers-Danlos syndrome.

While piezogenic papules are usually asymptomatic, associated pain has been reported.