Plasma cell vulvitis - Anogenital in
The etiology is unknown but is thought to be related to viral elements, trauma, and/or chronic irritation. The condition tends to be diagnosed in postmenopausal patients.
Patients can present with long-standing complaints of mild itching, pain, burning, and/or bleeding of the vulva. Symptoms may coincide with intercourse. Often, patients report just that a specific area of the vulva is uncomfortable or annoying. Many patients will be asymptomatic and unaware of any issues.
N76.3 – Subacute and chronic vulvitis
238921004 – Plasma cell vulvitis
Differential Diagnosis & Pitfalls
- Lichen sclerosus – Characteristic "figure-of-eight" distribution with fusion / regression of vulvar tissues.
- Vulvar atrophy – Usually more globally involved and can occur in vagina as well.
- Extramammary Paget disease
- Vulvodynia – No definitive lesion present but pain elicited using a cotton-tipped applicator.
- Lichen planus – Ulcerations will be present.
- Bowen disease
- Squamous cell carcinoma
- Allergic reaction / contact dermatitis
- Irritant contact dermatitis
- Vulvar intraepithelial neoplasia
- Herpes simplex
- Fixed drug eruption
- Pemphigus vulgaris
- Pemphigus foliaceus
- Mucous membrane pemphigoid
- Secondary syphilis
- Recessive dystrophic epidermolysis bullosa
- Junctional epidermolysis bullosa