Proximal renal tubular acidosis
Major causes of proximal RTA in adults include increased excretion of immunoglobulins in the setting of monoclonal gammopathies and use of carbonic anhydrase inhibitors (eg, acetazolamide, and topiramate or ifosfamide). In children, proximal RTA may be caused by an autosomal recessive mutation in the gene for the sodium bicarbonate transporter (SLC4A4) or ifosfamide use, although in many cases, no cause is identified.
Related topic: Distal renal tubular acidosis
N25.89 – Other disorders resulting from impaired renal tubular function
24790002 – Proximal renal tubular acidosis
Differential Diagnosis & Pitfalls
Drug Reaction Data