Prurigo nodularis in Child
Prurigo nodularis may be secondary to skin conditions associated with pruritus, such as atopic dermatitis and xerosis, as well as systemic conditions associated with generalized pruritus without a primary skin rash, such as psychiatric conditions, eating disorders, HIV infection, iron-deficiency anemia, diabetes mellitus, gluten enteropathy, thyroid disease, renal or hepatic impairment, malignancies, and others. In most cases, the etiology of pruritus is unknown. Studies have suggested that prurigo nodularis may be a form of subclinical small fiber neuropathy and that Th2 cytokines play an important role in its pathogenesis.
Lesions are firm dome-shaped, smooth-topped, or crusted nodules. Their size ranges from several millimeters to 1-2 cm, and they often enlarge slowly over time. Lichenification of the lesions is often not present.
Patients with this disorder may have an increased risk of various general medical conditions.
L28.1 – Prurigo nodularis
63501000 – Prurigo nodularis
Differential Diagnosis & Pitfalls
- Acne keloidalis nuchae
- Cutaneous horn
- Hypertrophic scars
- Various types of lymphoma
- Lymphomatoid papulosis
- Molluscum contagiosum
- Foreign body reactions
- Xanthomas (eruptive xanthoma, xanthoma tuberosum)
- Knuckle pads
- Multicentric reticulohistiocytosis
- Persistent insect bite reaction