Seborrheic dermatitis - Anogenital in
Infantile seborrheic dermatitis usually manifests in the second week of life and lasts 4-6 months. In infants, it characteristically presents on the face, diaper area, and folds of the neck and axillae.
Seborrheic dermatitis has a bimodal distribution, with peaks in infancy and adolescence / early adulthood. Although seborrheic dermatitis has been associated with HIV infection and neurologic disease, it typically presents in healthy individuals.
The yeast Malassezia has long been regarded as the central predisposing factor to disease development. Malassezia is a normal component of skin flora, but in individuals with seborrheic dermatitis, the yeast invades the stratum corneum, resulting in free fatty acid formation and the activation of the inflammatory cascade. Changes in the skin microbiome have also been implicated in pathogenesis. Additional factors related to the environment such as low temperatures and humidity have been identified as potential triggers.
L21.9 – Seborrheic dermatitis, unspecified
50563003 – Seborrheic dermatitis
Differential Diagnosis & Pitfalls
is extremely uncommon in neonates and infants. However, familial and genetically determined forms of psoriasis and other psoriasiform dermatitis do characteristically present with infantile psoriasis involving a similar distribution. The scaling is thicker in nonoccluded areas and plaques are better defined.
When localized in the diaper area, dermatoses to consider besides irritant contact dermatitis:
- – consider in those with particularly difficult-to-remove scales; examine the patient in locations characteristic for psoriasis
- - rare in infancy
Drug Reaction Data