Spitz nevus in Infant/Neonate
Spitz nevi most commonly arise during childhood and adolescence; congenital Spitz nevi present at birth are rare. The majority of lesions are solitary, but rarely they can be multiple and widespread (eruptive disseminated) or localized (agminated) in one area.
The importance of these lesions lies in their frequent histopathologic confusion with melanoma. Spitz nevi represent the benign diagnosis within a spectrum, which extends to contain increasingly atypical features in atypical Spitz tumors (ASTs) and Spitz melanomas.
Lesions can develop slowly or appear quite rapidly. Without excision, lesions may remain stable for years, evolve into compound nevi, flatten over time, or involute spontaneously.
Related topic: agminated nevus
D22.9 – Melanocytic nevi, unspecified
254811006 – Epithelioid and spindle cell nevus
Differential Diagnosis & Pitfalls
- Lobular capillary hemangioma (pyogenic granuloma)
- Nevus (congenital, acquired, dysplastic)
- Dermal nevus
- Melanoma or amelanotic melanoma
- Multiple Spitz nevi should be distinguished from urticaria pigmentosa, juvenile xanthogranuloma, and familial atypical nevus syndrome.