Splenic marginal zone lymphoma
SMZL is a very rare lymphoid neoplasm that occurs primarily in adults older than 50 years (median age is 67-68 years) with no sex predominance.
Patients present with splenomegaly and/or peripheral blood lymphocytes that appear villous. Thrombocytopenia and/or anemia may also be present. Patients are often asymptomatic at time of diagnosis, and initial abnormalities are identified incidentally on blood work.
An association between SMZL and chronic hepatitis C virus (HCV) has been identified in several case series, and in some cases, antiviral therapy for chronic HCV has resulted in regression of SMZL.
Related topics: Nodal marginal zone lymphoma; Extranodal marginal zone lymphoma
C83.07 – Small cell B-cell lymphoma, spleen
128802003 – Splenic marginal zone B-cell lymphoma
Differential Diagnosis & Pitfalls