Syringocystadenoma papilliferum (syringadenoma papilliferum) is a benign adnexal neoplasm commonly found on the head and neck or within a nevus sebaceus. Other common locations include the genital and inguinal skin.

These tumors are commonly present at birth or develop within the first several years of life, and they tend to enlarge during puberty. Clinical presentation is variable including papules, plaques, and verrucous lesions. Serous drainage from these lesions is not uncommon, but most are asymptomatic.

A few cases of malignant transformation to syringocystadenocarcinoma papilliferum have been reported; thus, surgical excision should be considered.

Special considerations in infants: Roughly one-half of all syringocystadenoma papilliferum tumors are present at birth. One-third of them arise in a nevus sebaceus.