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SynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyReferences

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Syringoma - External and Internal Eye
See also in: Overview,Anogenital
Other Resources UpToDate PubMed

Syringoma - External and Internal Eye

See also in: Overview,Anogenital
Contributors: Daniel Gutierrez MD, Mat Davey MD, Belinda Tan MD, PhD, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Syringomas are benign adnexal tumors derived from intraepidermal luminal cells of eccrine sweat ducts. They present as small, dome-shaped papules, often in a periorbital distribution. They may, however, occur at any site on the body. They are seen more frequently in women and in those with Down syndrome. Although usually sporadic, familial cases have been reported and inherited in an autosomal dominant manner. Treatment of these lesions is cosmetic.

Codes

ICD10CM:
D23.9 – Other benign neoplasm of skin, unspecified

SNOMEDCT:
302828001 – Syringoma of skin

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Nodular basal cell carcinoma – Pearly papule with telangiectasia and erosions on a background of sun-damaged skin.
  • Milia – Small, white cystic papules filled with keratin.
  • Xanthelasma palpebrarum – Favor upper eyelids; white to yellow plaques.
  • Sebaceous hyperplasia – Yellow umbilicated papule with crown vessels.
  • Steatocystoma multiplex – White to yellow smooth papules and nodules.
  • Flat wart – Characteristically flat-topped papules.
  • Trichoepithelioma – Favor alar creases; flesh-colored, rubbery papules.
  • Trichilemmoma – Common on the lips; may be verrucous.
  • Sarcoidosis – Infiltrative papules and plaques that can be seen around the nares. The micropapular variant may resemble syringomas.
  • Microcystic adnexal carcinoma – Should be considered if a solitary syringoma-like lesion appears on the lip.

Best Tests

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Management Pearls

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Therapy

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References

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Last Reviewed:10/21/2019
Last Updated:10/21/2019
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Syringoma - External and Internal Eye
See also in: Overview,Anogenital
A medical illustration showing key findings of Syringoma : Face, Smooth papules, Tiny papules, Cheeks
Clinical image of Syringoma - imageId=160788. Click to open in gallery.  caption: 'Many translucent and light brown papules on the cheek and inferior eyelid.'
Many translucent and light brown papules on the cheek and inferior eyelid.
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