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Targetoid hemosiderotic hemangioma
Other Resources UpToDate PubMed

Targetoid hemosiderotic hemangioma

Contributors: Kisha Kalra, Keith Morley MD, Susan Burgin MD
Other Resources UpToDate PubMed


Targetoid hemosiderotic hemangioma (THH), also known as targetoid hemosiderotic lymphatic malformation (THLM), is a benign lesion characterized clinically by a solitary central, brown-violaceous papule with or without a surrounding thin, pale area and ring of ecchymosis, creating a targetoid appearance. While THH was once thought to be of vascular origin, immunohistochemical data support its lymphatic origin, as THH stains positively for lymphatic markers including D2-40. Additionally, immunohistochemical studies have shown a pattern that is more consistent with a vascular malformation than a neoplasm, as implied by the term "hemangioma."

THH is a rare finding that tends to appear in young or middle-aged individuals. It has a predilection for the trunk and/or extremities. No definitive risk factors exist, although it is speculated that trauma may play a role in the development and flaring of these lesions.


D18.01 – Hemangioma of skin and subcutaneous tissue

254790003 – Targetoid hemosiderotic hemangioma

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Differential Diagnosis & Pitfalls

  • Lobular capillary hemangioma
  • Lyme disease
  • Erythema multiforme
  • Angiokeratoma
  • Angioendotheliomatosis
  • Sclerosing hemangioma
  • Mastocytosis in adults
  • Glomus tumor
  • Glomeruloid hemangioma
  • Arthropod bite or sting
  • Kaposi sarcoma (see AIDS-associated Kaposi sarcoma, Non-AIDS Kaposi sarcoma)
  • Angiosarcoma of skin
  • Other malignant vascular neoplasm, eg, Kaposiform hemangioendothelioma
  • Atypical nevus
  • Melanoma

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Last Reviewed:12/25/2021
Last Updated:01/17/2022
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Targetoid hemosiderotic hemangioma
A medical illustration showing key findings of Targetoid hemosiderotic hemangioma : Smooth papule, Targetoid configuration, Single skin lesion
Copyright © 2024 VisualDx®. All rights reserved.