Thrombophlebitis migrans
Alerts and Notices
Synopsis
There is very high association with malignancies including carcinomas, such as adenocarcinomas of the pancreas and lung carcinomas. Armand Trousseau first reported this phenomenon in 1865 when he commented that unexpected thrombophlebitis could indicate an occult visceral malignancy.
These malignancies are often associated with the development of a hypercoagulable state. The exact mechanism for this is not fully elucidated. However, it is postulated that the tumors may secrete procoagulant factors, such as thromboplastin, that can lead to local clotting.
Related topic: Superficial Thrombophlebitis
Codes
ICD10CM:I82.1 – Thrombophlebitis migrans
SNOMEDCT:
31268005 – Thrombophlebitis migrans
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Deep venous thrombosis / thrombophlebitis of other origin
- Cellulitis
- Lymphangitis
- Soft tissue injury
- Septic thrombophlebitis
- Erythema nodosum
- Hematoma
- Venous insufficiency / varicose veins
- Postphlebitic (thrombotic) syndrome
- Panniculitis
- Urticaria
- Contact dermatitis (allergic, irritant)
- Eosinophilic cellulitis
- Lipodermatosclerosis
- Thromboangiitis obliterans
- Erythema induratum
- Herpesvirus infections (herpes simplex virus, herpetic whitlow, zoster) may demonstrate lymphangitic streaking
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Therapy
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References
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Last Reviewed:12/05/2016
Last Updated:12/05/2016
Last Updated:12/05/2016