Approximately 1 of 10 000 patients who receive warfarin develop this reaction. Some patients have an associated protein C or protein S deficiency. Women are affected more often than men.
Once necrosis has occurred, the continued use of warfarin does not seem to cause additional lesions to develop. Lesions heal by granulation over weeks.
T45.515A – Adverse effect of anticoagulants, initial encounter
403659005 – Coumarin necrosis
Differential Diagnosis & Pitfalls
Drug Reaction Data