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Germinoma
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Germinoma

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Contributors: Andrea Wasilewski MD, Jamie Adams MD, Richard L. Barbano MD, PhD
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Synopsis

Germinoma : Headache, Papilledema, Personality changes, Anorexia, Upward gaze paralysis
Germinoma is a malignant germ cell tumor arising in the midline, largely in the pineal or suprasellar regions of the central nervous system, characterized by the presence of primitive, large, malignant germ cells and lymphocytes. Germinomas can often cause obstructive hydrocephalus presenting with severe headache, nausea, vomiting, papilledema, and changes in mental status. Other findings include ataxia, fatigue, weight loss, upward gaze paralysis, increased intracranial pressure, and vision loss. Germinomas occur in young patients between the ages of 10 and 20, with males affected more often than females.

Treatment includes surgical resection, radiation, and chemotherapy. Germinomas may reoccur after therapy.

Codes

ICD10CM:
C71.6 – Malignant neoplasm of cerebellum

SNOMEDCT:
28307001 – Germinoma

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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References

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Last Reviewed:03/10/2019
Last Updated:04/19/2021
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Germinoma
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A medical illustration showing key findings of Germinoma : Headache, Papilledema, Personality changes, Anorexia, Upward gaze paralysis
Copyright © 2023 VisualDx®. All rights reserved.