Nasal polyp in Adult
The majority of cases are associated with edema and eosinophilic infiltration. Although the precise cause of formation is unknown, the etiology of nasal polyps is regarded as multifactorial and as being linked with chronic mucosal inflammation. Contributing factors may include cytokine mediators, innate immune defects, infection, genetic factors, environmental exposures, and inflammatory conditions.
Nasal polyps are frequently associated with chronic sinusitis, asthma, aspirin sensitivity, nonallergic (eg, vasomotor, drug induced) and allergic rhinitis and rhinosinusitis, cystic fibrosis, and alcohol intolerance.
J33.9 – Nasal polyp, unspecified
736499003 – Polyp of nasal cavity and/or nasal sinus
Differential Diagnosis & Pitfalls
- Papilloma – they are irregular and friable in appearance and bleed easily
- Meningoencephalocele (see meningocele, encephalocele) – grayish, gelatinous appearance
- Nasopharyngeal carcinoma – firm, often ulcerated
- Pyogenic granuloma
- Chordoma – gelatinous appearance, arises from notochordal (embryonic) remnants
- Benign lesions such as mucous retention cyst, antrochoanal polyp, mucocele, Tornwaldt cyst (located in the midline of the nasopharynx), dacryocystocele, osteoma, schneiderian papilloma, juvenile nasopharyngeal angiofibroma, hemangiopericytoma, capillary hemangioma, and cavernous hemangioma and those associated with granulomatosis with polyangiitis and sarcoidosis.
- Malignant lesions such as squamous cell carcinoma, adenoid cystic carcinoma, adenocarcinoma, lymphoma, melanoma, and fibrous histiocytoma.
Drug Reaction Data