While the overwhelming majority of neurogenic ulcers occur in individuals with diabetes, any condition resulting in polyneuropathy (alcohol use disorder, arsenic poisoning, etc) or local neuropathy (eg, herpes zoster, Hansen disease) will predispose an individual to their formation.
Neurogenic ulcers are difficult to treat, frequently recur, and result in significant morbidity in the form of loss of function and, often, loss of limb.
E13.621 – Other specified diabetes mellitus with foot ulcer
15074003 – Neurogenic ulcer
Differential Diagnosis & Pitfalls
- Venous, or stasis, ulcer
- Arterial ulcer
- Pressure ulcer (decubitus ulcer)
- Pyoderma gangrenosum
- Acral lentiginous melanoma
- Necrobiosis lipoidica
- Basal cell carcinoma
- Squamous cell carcinoma / Marjolin ulcer
- Drug-induced cutaneous necrosis (Coumadin necrosis, heparin necrosis)
- Hereditary sensory neuropathy