Peripheral arterial disease
Alerts and Notices
Synopsis

Peripheral arterial disease (PAD) is a clinical disorder leading to stenosis or occlusion of the noncardiac vessels. Atherosclerosis is the most common cause in adults over the age of 40 years. Risk factors for developing PAD include age older than 70 years, family history, smoking, diabetes, hypertension, hyperlipidemia, and homocysteinemia.
Symptoms develop when the metabolic demand of tissues is greater than vessels are able to deliver. Most patients with PAD are asymptomatic. In those who develop symptoms, look for extremity pain with activity that is relieved with rest (claudication), limb ischemia with the development of ulcers or gangrenous lesions, or critical acute limb ischemia leading to pallor, pulselessness, paresthesia, and poikilothermia.
Atherosclerosis is a type of arteriosclerosis that can lead to narrowing of blood vessels. When atherosclerotic plaques involve 70%-80% of the luminal diameter, blood flow may become limited, particularly during times of physical exertion and increased demand. Plaque rupture may cause occlusion of coronary vessels or cerebrovascular vessels, leading to ischemia and infarction that present as myocardial infarctions and strokes, respectively.
Symptoms develop when the metabolic demand of tissues is greater than vessels are able to deliver. Most patients with PAD are asymptomatic. In those who develop symptoms, look for extremity pain with activity that is relieved with rest (claudication), limb ischemia with the development of ulcers or gangrenous lesions, or critical acute limb ischemia leading to pallor, pulselessness, paresthesia, and poikilothermia.
Atherosclerosis is a type of arteriosclerosis that can lead to narrowing of blood vessels. When atherosclerotic plaques involve 70%-80% of the luminal diameter, blood flow may become limited, particularly during times of physical exertion and increased demand. Plaque rupture may cause occlusion of coronary vessels or cerebrovascular vessels, leading to ischemia and infarction that present as myocardial infarctions and strokes, respectively.
Codes
ICD10CM:
I73.9 – Peripheral vascular disease, unspecified
SNOMEDCT:
399957001 – Peripheral arterial occlusive disease
I73.9 – Peripheral vascular disease, unspecified
SNOMEDCT:
399957001 – Peripheral arterial occlusive disease
Look For
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Cervical or lumbar spinal stenosis
- Peripheral neuropathy
- Venous thrombosis
- Osteoarthritis
- Reflex sympathetic dystrophy
- Arterial dissection (see, eg, carotid artery dissection, aortic aneurysm dissection)
- Thromboembolism
- Vasospasm
- Vasculitis (see thromboangiitis obliterans, Kawasaki disease, giant cell arteritis)
Best Tests
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Management Pearls
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Therapy
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.
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References
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Last Reviewed:04/23/2019
Last Updated:09/11/2019
Last Updated:09/11/2019

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