Potentially life-threatening emergency
Pneumothorax
Alerts and Notices
Synopsis
Primary spontaneous pneumothorax typically occurs in patients without underlying lung disease. Classic presentation includes a tall, thin, young male patient in his teens or 20s. The spontaneous rupture of subpleural apical blebs or bullae may result from an inherited cause (eg, Marfan syndrome) or smoking or drug use. Primary spontaneous pneumothorax will typically occur while a patient is at rest; however, it may occur during physical activities such as reaching or stretching. Pressure changes in the lung that occur during diving and flying at high altitudes may also bring about primary spontaneous pneumothorax.
Secondary spontaneous pneumothorax usually occurs in patients with underlying lung diseases, such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, Pneumocystis jirovecii infection, tuberculosis, or whooping cough. This often occurs secondary to bleb rupture. Pneumothorax has been reported as a complication of chemotherapy. Other drugs have also been implicated. Secondary spontaneous pneumothorax is typically more serious than primary spontaneous pneumothorax.
Catamenial pneumothorax is a rare form of spontaneous pneumothorax occurring most commonly after the onset of menstruation in premenopausal women and less commonly in menopausal women taking estrogen. It is caused by intrathoracic endometriosis.
Traumatic pneumothorax is a complication of a blunt or penetrating chest injury.
Iatrogenic pneumothorax is caused by medical procedures, such as central venous catheter placement, mechanical ventilation, transthoracic needle aspiration, and cardiopulmonary resuscitation.
Related topic: Tension pneumothorax
Codes
ICD10CM:J93.9 – Pneumothorax, unspecified
SNOMEDCT:
36118008 – Pneumothorax
Look For
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Pulmonary embolism – Also causes acute-onset dyspnea and chest pain / discomfort but with different imaging and physical exam findings and different risk factors.
- Hemothorax – Filling of pleural space with blood instead of air.
- Myocardial infarction – Also causes acute-onset dyspnea and chest pain / discomfort but with different imaging and physical exam findings and different risk factors.
- Aortic dissection – Also causes acute-onset dyspnea and chest pain / discomfort but with different imaging and physical exam findings and different risk factors.
- Cardiac tamponade – Also causes acute-onset dyspnea and chest pain / discomfort but with different imaging and physical exam findings and different risk factors.
- Status asthmaticus
- Bullous emphysema with acute cause of worsened respiratory status (ie, infection or bronchospasm)
Best Tests
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Management Pearls
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Therapy
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.Subscription Required
References
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Last Reviewed:08/24/2017
Last Updated:09/21/2017
Last Updated:09/21/2017
Potentially life-threatening emergency
Pneumothorax